Evidence for Posttranslational Control of Hb C Synthesis in an Individual With Hb C Trait and a - Thalassemia
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چکیده
The level of Hb C in the erythrocytes of individuals with Hb C trait decreases significantly in the presence of coexisting a-thalassemia. This relationship may result from the higher affinity of 9A than c for limiting amounts of a-globin during hemoglobin assembly. This mechanism would predict that the 1 A and synthetic capacity in a-thalassemic individuals with Hb C trait should be balanced despite the low levels of Hb C in their circulating erythrocytes. To directly
منابع مشابه
Evidence for posttranslational control of Hb C synthesis in an individual with Hb C trait and alpha-thalassemia.
The level of Hb C in the erythrocytes of individuals with Hb C trait decreases significantly in the presence of coexisting alpha-thalassemia. This relationship may result from the higher affinity of beta A than beta C for limiting amounts of alpha-globin during hemoglobin assembly. This mechanism would predict that the beta A and beta C synthetic capacity in alpha-thalassemic individuals with H...
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